Protective effects of HBSP on ischemia reperfusion and cyclosporine a induced renal injury.
RatIschaemia-reperfusionRenalSprague-Dawleymalen = n = 6 per group across 4 groups (IR, IR + CsA, IR + HBSP, I…intraperitoneal8 nmol/kgCommenced after reperfusion
Model: Right renal pedicle occlusion for 45 min with left nephrectomy before reperfusion, followed by 2 weeks of reperfusion, with or without daily cyclosporine A 25 mg/kg by gavage
HBSP reduced blood urea nitrogen in the IR + CsA group at 1 and 2 weeks (8.0 +/- 0.9 and 9.4 +/- 1.7 versus 14.4 +/- 1.4 and 14.7 +/- 0.9 mmol/L) and lowered the urinary protein/creatinine ratio at 2 weeks. It reduced the tubulointerstitial damage score (3.5 +/- 0.3 versus 5.5 +/- 0.5), collagen de…
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