Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.
MouseRadiationC57BL/6 (H-ARS studies); B6.BoyJ (B6.Ptrc Pep3/BoyJ) and C57BL/6 x B6.BoyJ F1 hybrid used as transplant recipients and competitor cell donorsMale and female (50/50)n = Groups of 20-30 mice per arm in the PEGylated G-CSF surviva…SubcutaneousMaxy-G34 and Neulasta 0.1, 0.3 or 1.0 mg/kg; Neupogen 125 u…First dose 24 +/- 4 h after total body irradiation
Model: Single uniform total body gamma irradiation (137Cs, 7.76-9.04 Gy, 0.60-0.66 Gy/min) producing the haematopoietic syndrome of the acute radiation syndrome (H-ARS)
All three growth factors significantly increased 30-day survival after lethal irradiation. Neupogen gave 80.2 per cent 30-day survival versus 51.6 per cent for vehicle (p=0.02, 212 pooled irradiated mice). A single 1.0 mg/kg dose of Neulasta at 24 h was as effective as two doses (p=0.003 and p=0.00…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.