PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.
MouseRadiationC57BL/6Male and female (50/50)n = Survival group sizes not explicitly stated; studies powered…Subcutaneous0.1, 0.3 or 1.0 mg/kg depending on agent and scheduleFirst dose at 24 to 28 h (24 + 4 h) after total body irradiation
Model: Single dose uniform total body gamma irradiation (137Cs, 7.76-8.72 Gy, 0.62-1.02 Gy/min) producing the haematopoietic syndrome of the acute radiation syndrome (H-ARS)
All three PEGylated growth factors significantly improved 30-day survival. Nine doses of PEG-G-CSF gave 70 per cent (0.1 mg/kg) and 63 per cent (0.3 mg/kg) survival versus 28 per cent for vehicle (p<0.001), and a single dose gave 95 per cent (0.3 mg/kg) and 100 per cent (1.0 mg/kg) versus 65 per ce…
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