Immunosuppression does not affect human bone marrow mesenchymal stromal cell efficacy after transplantation in traumatized mice brain.
MouseTBIUnspecifiedC57Bl/6MaleIntracerebroventricular infusion150,000 cells in 5 microlitres24 h after injury
Model: Traumatic brain injury (controlled experimental TBI with sham surgery controls)
hMSC produced comparable functional recovery (sensorimotor and cognitive) and structural protection (reduced contusion volume, vessel rescue, reduced gliotic scar, increased neurogenesis) in both immunocompetent and immunosuppressed mice, indicating long-term efficacy is not dependent on immunosupp…
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