How important is differentiation in the therapeutic effect of mesenchymal stromal cells in liver disease?
MouseOtherBALB/cMale
Model: Fulminant hepatic failure mouse model
Undifferentiated MSC showed superior rescuing potential to hepatocyte-like cells in fulminant hepatic failure; after hepatic differentiation, HLC expressed lower hepatocyte growth factor and had impaired immunosuppressive capacity.
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