Effect of norepinephrine on spinal cord blood flow and parenchymal hemorrhage size in acute-phase experimental spinal cord injury.
RatSpinal cord injuryContusionWistarMalen = 38 animals across four groupsInfusion (route not specified in abstract)Started 15 min after trauma
Model: Weight-drop contusion spinal cord injury at Th10 (10 g weight dropped from 10 cm)
Spinal cord injury significantly decreased spinal cord blood flow (P = 0.0002). Norepinephrine infusion did not significantly modify spinal cord blood flow, and parenchymal haemorrhage size was significantly greater in animals given norepinephrine (P = 0.0002).
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