Infusion of Trx-1-overexpressing hucMSC prolongs the survival of acutely irradiated NOD/SCID mice by decreasing excessive inflammatory injury.
MouseRadiationNOD/SCIDmalen = Redox capacity experiment: four groups of six male miceInjection (systemic infusion)0.2 ml normal saline containing hucMSC-Trx-1 or unmodified…
Model: Acute radiation injury from 4.5 Gy whole-body cobalt-60 gamma irradiation
hucMSC-Trx-1 gave superior antioxidant capacity, protected bone marrow haematopoietic stem cells (versus hucMSC p<0.05; versus saline p<0.01), promoted red blood cell and haemoglobin formation (p<0.05 versus both comparators), reduced inflammation and damage in bone marrow and lung (versus saline p…
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