Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarmaleIntraperitoneal10 mg/kgFirst dose 2 hours after embolic middle cerebral artery occlusion
Model: Embolic middle cerebral artery occlusion in rats with streptozotocin-induced type 1 diabetes (streptozotocin 60 mg/kg intraperitoneally)
Neamine significantly decreased blood-brain barrier leakage and lesion volume and improved functional outcome compared with diabetic controls. It reduced apoptosis and cleaved caspase-3, decreased nuclear angiogenin, NF-kappaB activity, RAGE and TLR4, and increased angiopoietin-1, with Western blot…
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