Amniotic fluid stem cells prevent beta-cell injury.
MouseChemical/toxinNOD/SCID (NOD.CB17-Prkdc/J)n = One reported cohort of n=4 AFSC-injected, n=4 streptozotoci…Intracardiac injection through the chest wall into the left ventricleCell injections of AFSC or fibroblasts in saline solution,…Injected 14 days after streptozotocin treatment in the reported cohort; protect…
Model: Streptozotocin-induced beta-cell injury and type 1 diabetes (streptozotocin 50 mg/kg body weight intraperitoneally on 3 consecutive days, mice fasted 4 hours before each injection)
AFSC injection protected against beta-cell damage and increased beta-cell regeneration in a subset of mice, indicated by glucose and insulin levels, increased islet mass and preserved islet structure. Beta-cell preservation and regeneration correlated with activation of the insulin receptor/PI3K/Ak…
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