Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer.
MouseRadiationInjectionAdministered before irradiation
Model: Ionising radiation-induced acute gastrointestinal syndrome; parallel orthotopic xenograft model of prostate cancer
Darinaparsin given before irradiation accelerated recovery from body weight loss and increased survival in the radiation-induced gastrointestinal syndrome model, and decreased post-irradiation DNA damage and cell death in crypt epithelial cells. Cell cycle arrest at G1/S and G2/M with induction of…
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