Delta opioid receptor agonist BW373U86 attenuates post-resuscitation brain injury in a rat model of asphyxial cardiac arrest.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleymaleAcute treatment given immediately after restoration of spontaneous circulation
Model: Asphyxial cardiac arrest induced by 8 minutes of asphyxiation followed by cardiopulmonary resuscitation, producing global cerebral ischaemic post-resuscitation brain injury
Asphyxial cardiac arrest caused massive neuronal loss and marked neurological deficits. BW373U86 significantly reduced both and increased hippocampal CREB and phosphorylated CREB. These acute effects were reversed by naltrindole, whereas the protection from chronic treatment persisted to 28 days af…
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