Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats
RatIschaemia-reperfusionRenalSprague-DawleyMale and femaleIntravenous bolus injection0.5 mg/kg5 minutes before ischaemia
Model: Ischaemic acute kidney injury by clamping the left renal artery and vein for 45 or 60 minutes followed by reperfusion, two weeks after contralateral nephrectomy
Renal dysfunction and histological damage occurred in both sexes but were more marked in males. Pre-ischaemic oligomycin 0.5 mg/kg markedly attenuated ischaemia-reperfusion renal injury in male rats and partly but significantly suppressed ischaemia induced renal ATP depletion in males, with no prot…
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