Group VIB Ca2+-independent phospholipase A2 gamma is associated with acute lung injury following trauma and hemorrhagic shock
RatHaemorrhage/shockControlledSprague-DawleyMale30 minutes before trauma and haemorrhagic shock or trauma with sham shock
Model: Trauma and haemorrhagic shock with mesenteric lymph duct and vascular cannulation, midline laparotomy plus haemorrhage to mean arterial pressure 35 mmHg for 30 minutes then 2 hours of resuscitation with shed blood and twice the volume of normal saline
Trauma and haemorrhagic shock increased 2-polyunsaturated lysophosphatidylcholines and arachidonic acid in post-haemorrhagic shock mesenteric lymph. Pre-treatment with R-BEL significantly reduced these lipid mediators and inhibited acute lung injury judged by lung vascular permeability, myeloperoxi…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.