The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion
RatCrushOther / unspecifiedLong-EvansMalen = n = 9 to 12 per group, experiments repeated at least three…Intraperitoneal10 mg/kg body weightAdministered concurrently with lung contusion, during the same anaesthetic peri…
Model: Non-lethal bilateral closed-chest lung contusion induced by dropping a 300 g hollow cylindrical aluminium weight from 80 cm onto the chest (impact energy 2.2 J) under halothane anaesthesia, with a plastic shield protecting mediastinal structures
MnTBAP significantly reduced lavage albumin at 24 hours, lowered IL-1beta, IL-6, CINC-1 and CINC-3, reduced lavage macrophages at 5 hours and neutrophils at 24 hours, decreased neutrophil-rich exudate and tissue damage on histology at 24 hours, reduced dihydroethidium superoxide fluorescence at 5 a…
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