The protective effect of VSL#3 on intestinal permeability in a rat model of alcoholic intestinal injury
RatChemical/toxinMalen = 56 rats total, 8 per group across 7 groupsIntragastric via stomach tubeVSL#3 0.6 g/kg; glutamine 0.3 g/kg; heat-killed VSL#3 0.6 g…30 minutes before each alcohol administration, prophylactic
Model: Acute alcoholic intestinal and liver injury induced by three intragastric doses of 40 percent alcohol at 5 g/kg body weight given every 12 hours after a 12 hour fast
Alcohol raised plasma TNF-alpha (383.08 +/- 20.21 versus control 174.69 +/- 20.68) and endotoxin (1.57 +/- 0.11 versus 0.19 +/- 0.10) and reduced occludin and ZO-1 mRNA and protein. VSL#3 (TNF-alpha 201.54 +/- 26.56, endotoxin 0.34 +/- 0.10), heat-killed VSL#3 and glutamine each significantly rever…
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