Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury
MouseSpinal cord injuryUnspecifiedC57BL/6Subacute phase of secondary injury; exact administration time not stated
Model: Experimental spinal cord injury in a mouse model, with in vitro and in vivo assessment of the subacute phase of secondary injury
Minocycline loaded nanoparticles reduced activation and proliferation of microglia and macrophages around the lesion site, shifted cells from a round phagocytic-like phenotype towards an arborised resting-like phenotype with low CD68 staining, and reduced proinflammatory IL-6 expression with persis…
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