Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350)
MouseRadiationC57BL/6NHsd; C57BL/6-Luc+GFP+ donors for luciferase marrow chimerasn = Fibrosis scoring in 4 animals per group at acute and latent…Oral in drinking water for the thoracic irradiation fibrosis experiments; intraperitoneal for the total-body irradiation mitigation experiment400 micromolar in drinking water, estimated intake 213 to 5…Single intraperitoneal injection 24 hours after 9.5 Gy total-body irradiation;…
Model: Ionizing radiation injury, 9.5 Gy single-fraction total-body irradiation (LD100/30) and 20 Gy single-fraction thoracic irradiation causing late pulmonary fibrosis, with 16 Gy thoracic in the marrow chimera experiment
MMS350 acted as both protector and mitigator of bone marrow stromal cells in vitro, significantly improved survival when given 24 hours after 9.5 Gy total-body irradiation (P = 0.0097), and when added to drinking water from day 100 after 20 Gy thoracic irradiation significantly reduced late pulmona…
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