Simvastatin attenuates radiation-induced tissue damage in mice.
MouseRadiationC57BL/6JMaleIntragastric20 mg/kg/dayPretreatment for 14 days before irradiation
Model: Total body cobalt gamma irradiation at 4 Gy or 8 Gy, causing gastrointestinal and haematopoietic acute radiation injury
Simvastatin 20 mg/kg/day for 14 days preserved jejunal crypt-villus height and reduced apoptosis after 4 Gy and 8 Gy, restored bone marrow structure and reduced marrow apoptosis, increased red blood cells and haemoglobin after 4 Gy without changing white cells or platelets, increased circulating en…
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