TGF-beta3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats.
RatWoundFischer 344Malen = 8 to 10 rats per group in the treatment experiment, with 5…Direct injection into the vocal fold lamina propria or wound bed under endoscopic guidance using a 26-gauge needle1 microlitre of 50 ng per microlitre, that is 50 ng per inj…3 minutes before injury, immediately after injury, 24 h after injury and 48 h a…
Model: Bilateral or unilateral vocal fold mucosal stripping injury under endoscopic guidance, with 2 cm oral mucosal and skin incision injuries for cross-tissue comparison
TGF-beta3 treatment reduced Emr1 transcription at 72 h, indicating less macrophage infiltration, and upregulated Fn1, Has1 and Has2. At 60 days the treated vocal fold mucosa had greater lamina propria cross-sectional area, less muscle fibre invasion, reduced Col3a1 transcription and collagen type I…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.