PRECLINICAL PUBLICATION · 2013

Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human mesenchymal stem cells, minimally manipulated from vertebral body bone marrow, with or without preactivation using serum from patients with acute respiratory distress syndrome

PMID 24089414 ↗2013Reported benefit

Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels.

MouseEndotoxin/LPSC57BL/6FemaleIntravenous injection

Model: Endotoxaemia-induced acute lung injury as a murine model of acute respiratory distress syndrome

Minimally manipulated and preactivated human mesenchymal stem cells reduced lung injury score, pulmonary oedema and bronchoalveolar inflammatory cells and cytokines more effectively than conventionally expanded or non-activated cells.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.