The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.
MouseTBIControlled cortical impactOral administrationImmediately after traumatic brain injury, and also effective when first given 8…
Model: Controlled cortical impact traumatic brain injury in cathepsin B gene knockout and wild-type mice
Cathepsin B gene deletion and oral E64d each improved motor function, reduced lesion volume and preserved neuronal density after controlled cortical impact, with E64d effective when given up to 8 h post-injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.