Repeated Baclofen treatment ameliorates motor dysfunction, suppresses reflex activity and decreases the expression of signaling proteins in reticular nuclei and lumbar motoneurons after spinal trauma in rats.
RatSpinal cord injuryComplete transectionWistarMaleOral, in drinking water30 mg per body weight as reported by the authors, diluted i…Started at week 1 after injury
Model: Complete spinal cord transection at the Th9 level
Repeated discontinuous baclofen improved motor function and suppressed reflex activity, with a considerable decrease in neuronal nitric oxide synthase staining correlating with improved motor dysfunction.
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