Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion.
RatSpinal cord injuryContusionFischer 344Femalen = 74 rats in total; 6 per group at the 2 week time point and…Intraspinal injection into the centre of the lesion using a 5 microlitre Hamilton syringe in a stereotaxic frame5 microlitres of cell suspension injected over 3 minutes; t…14 days after contusion, that is sub-acute
Model: T10 laminectomy followed by moderate contusion with the New York University impactor, 10 g weight dropped from 12.5 mm
Both olfactory ensheathing glia and Schwann cell grafts increased spared tissue volume, retrogradely labelled supraspinal neurons (3019 plus or minus 216 and 2767 plus or minus 411 versus 1204 plus or minus 331 in injury only) and BBB scores, but did not improve ladder walking, and Schwann cells in…
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