Ameliorative effect of ferulic acid against renal injuries mediated by nuclear factor-kappaB during glycerol-induced nephrotoxicity in Wistar rats.
RatChemical/toxinWistarMale5, 10, 15, 20 and 25 mg/kg body weightGiven with glycerol, with the animals sacrificed 24 h later
Model: Myoglobinuric acute renal failure induced by intramuscular injection of 8 mL/kg body weight of 50 per cent glycerol
Ferulic acid reduced glycerol-induced renal dysfunction, lipid peroxidation and nuclear factor kappa B expression and restored antioxidant enzyme activities in a dose-dependent manner.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.