Effects of bone marrow stromal cell transplantation through CSF on the subacute and chronic spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-Dawley, with donor cells from GFP-transgenic Sprague-Dawley ratsFemale recipientsn = 99 rats in total with 10 deaths; 1 week group 30 treated an…Injection into the cerebrospinal fluid through the fourth ventricle, using a 29-gauge needle inserted 6 mm from the cerebellar surface through a skull pore 3.5 mm caudal to lambdaCell suspension of 50 microlitres of phosphate buffered sal…First injection at 1, 2 or 4 weeks after injury, corresponding to subacute and…
Model: Contusion spinal cord injury after Th8 to Th9 laminectomy under isoflurane anaesthesia, using the New York University impactor with a 10 g weight dropped from 7.5 cm
Bone marrow stromal cell infusion into the cerebrospinal fluid improved BBB scores at all three treatment times, reduced cavity volume and increased axon density in the astrocyte-devoid epicentre (291.6 plus or minus 64.7 versus 65.5 plus or minus 15.3 per 0.25 square mm), despite no long-term cell…
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