Protective effect of N-acetylserotonin against acute hepatic ischemia-reperfusion injury in mice.
MouseIschaemia-reperfusionHepaticKunmingMalen = 18 mice in total, n = 6 per group across three groups (sham…Intraperitoneal5 mg/kg (preliminary work compared 5, 10 and 20 mg/kg; 20 m…30 min before induction of ischaemia (pre-treatment)
Model: Hepatic ischaemia-reperfusion produced by clamping the hepatic artery, portal vein and common bile duct with a microvascular bulldog clamp for 30 min followed by 6 h reperfusion
N-acetylserotonin preserved hepatic architecture, lowered the apoptosis index from 25.8 +/- 3.5% to 12.7 +/- 1.0% (sham 1.5 +/- 0.3%), reduced serum AST, reduced malondialdehyde from 2.4 +/- 0.5 to 1.4 +/- 0.2 nmol/mg protein, raised superoxide dismutase from 68.6 +/- 15.9 to 91.6 +/- 13.9 U/mg pro…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.