Acute Lonomia obliqua caterpillar envenomation-induced physiopathological alterations in rats: evidence of new toxic venom activities and the efficacy of serum therapy to counteract systemic tissue damage.
RatChemical/toxinWistarMaleAdministered up to 2 h after venom injection in the effective arm; a later arm…
Model: Acute Lonomia obliqua caterpillar venom injection producing systemic haemorrhage, intravascular haemolysis, myotoxicity, genotoxicity and acute kidney injury
Antivenom given up to 2 h after venom injection neutralised the biochemical alterations. Treatment at 6 h reversed coagulation dysfunction but failed to normalise all biochemical parameters, indicating time-dependent efficacy of serum therapy.
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