Evaluation of the wound healing property of Boesenbergia longiflora rhizomes.
MixedChemical/toxinWistar (rat)Male and femaleChloroform fraction ED50 222.7 mg/kg for carrageenan paw oe…
Model: Carrageenan-induced hind paw oedema in rats, with in vitro scratch/fibroblast migration wound healing assays in L929 cells and nitric oxide inhibition in RAW264.7 macrophages
The chloroform fraction inhibited nitric oxide production (IC50 5.5 ug/ml), reduced carrageenan paw oedema (ED50 222.7 mg/kg) and increased fibroblast migration (77.3% at day 1, 100% at day 2) and collagen production (187.5 ug/ml) relative to controls.
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