Agar-based bridges as biocompatible candidates to provide guide cues in spinal cord injury repair.
RatSpinal cord injuryComplete transectionWistarMaleSurgical implantation into the transection gapAt the time of transection (acute implantation)
Model: Acute complete spinal cord transection at thoracic level T8
All mixtures except agar plus gelatin were stable and porous and elicited a low host reaction with peripheral sensory (CGRP-positive) neurite ingrowth, but central axons did not cross into the bridges, collagen accumulated in the channels and channel linearity was lost.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.