Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival.
MouseRadiationCD2F1Male200 mg/kg, single dose24 h before irradiation
Model: Whole-body gamma irradiation at 11 Gy causing gastrointestinal toxicity, with jejunum sampled at 4 and 24 h
Gamma-tocotrienol given 24 h before 11 Gy whole-body irradiation up-regulated anti-apoptotic and down-regulated pro-apoptotic gene and protein expression at 4 and 24 h, with reduced TUNEL positivity and preserved jejunal crypts.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.