Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy.
MouseChemical/toxinMalePre-treatment before streptozotocin
Model: High-dose streptozotocin-induced acute renal toxicity within a diabetic nephropathy model, with associated gastric dilatation and delayed gastric emptying
Phlorizin pre-treatment reduced renal streptozotocin uptake and resolved the direct kidney toxicity and gastric dilatation while increasing pancreatic uptake, allowing diabetic nephropathy to be induced with a single non-nephrotoxic streptozotocin dose of 70 mg/kg.
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