Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart.
RatRadiationSprague-DawleyMalen = Enteropathy model: 8 groups, n = 5 sham and 13 to 15 irradi…Oral (gavage for the first 3 weeks, then in chow)10 mg/kg body weight per day (delivered in chow at 125 mg/k…Started 3 days before irradiation
Model: Localised irradiation of a 4 cm ileal loop with 7 once-daily fractions of 5.6 Gy (radiation enteropathy), and localised heart irradiation with a single 18 Gy dose (radiation-induced heart disease)
Xaliproden raised circulating TGF-beta1 by about 300% and worsened radiation injury, increasing intestinal injury score, wall and subserosal thickening, collagen I and III and myeloperoxidase-positive cells while reducing mucosal surface area, and increasing cardiac myofibroblasts, wall stress and…
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