Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMaleIntravenous injection2 million cells per kilogram body weight, harvested from th…72 h after injury
Model: Controlled cortical impact traumatic brain injury
Intravenous autologous bone marrow mononuclear cells reduced blood-brain barrier permeability at 96 h, increased apoptosis of activated microglia in the ipsilateral hippocampus and improved Morris water maze probe performance at 4 weeks.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.