Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
RatChemical/toxinSprague-DawleyMalen = Six groups of rats; group sizes not statedGinger 100 mg/kg; vitamin E 75 mg/kgPre-treatment before acetaminophen
Model: Acetaminophen-induced acute hepatotoxicity, 600 mg/kg as a single intraperitoneal injection
Pre-treatment with ginger or vitamin E lowered plasma ALT, AST, alkaline phosphatase, arginase and total bilirubin, reduced malondialdehyde, restored triacylglycerols and total protein and decreased hepatic necrosis and vacuolisation.
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