Anti-C5a complementary peptide ameliorates acute peritoneal injury induced by neutralization of Crry and CD59.
RatOtherSprague-Dawleymaleintravenousadministered up to 4 h after induction of injury
Model: Acute peritoneal injury induced by neutralisation of the membrane complement regulators Crry and CD59
Intravenous AcPepA given up to 4 h after injury significantly and dose-dependently prevented inflammatory cell accumulation and reduced peritoneal tissue damage, with decreased C3b deposition.
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