Posttraumatic reduction of edema with aquaporin-4 RNA interference improves acute and chronic functional recovery.
RatTBIControlled cortical impactSprague-Dawleyinjection lateral to the trauma siteafter controlled cortical impact
Model: Controlled cortical impact juvenile traumatic brain injury
siAQP4 improved motor function at 3 days and spatial memory at 60 days compared with siGLO controls, with reduced oedema, less blood-brain barrier disruption, reduced astrogliosis and neuronal death, and about 30 per cent lower AQP4 expression at the injection site.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.