Monitoring tissue inflammation and responses to drug treatments in early stages of mice bone fracture using 50 MHz ultrasound.
MouseFractureTibiaC57BL/6N (B6)femalen = 18 mice in total, with data from three independent animals…oralaspirin 100 to 400 mg/kg/day; indomethacin 1.5 to 2 mg/kg/d…started after the fracture was produced
Model: Closed mid-shaft tibial fracture stabilised with a 0.20 mm intramedullary steel pin, produced with a free-dropping impact injury simulator under chloral hydrate anaesthesia and confirmed by X-ray
Aspirin significantly reduced fracture-induced hyperechogenicity, with day 7 echogenicity of 1.14 plus or minus 0.29 fold versus 1.71 plus or minus 0.21 fold in untreated fractured mice, and also inhibited cell death and COX-2 and BLT1 expression. Indomethacin and SC-236 did not reduce hyperechogen…
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