Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarPreconditioning 3 weeks before the ischaemia-reperfusion insult
Model: Ischaemic preconditioning by occlusion of the left internal carotid artery for 20 min (sham 2 seconds), followed 3 weeks later by left middle cerebral artery occlusion for 45 min and 24 h reperfusion
Ischaemic preconditioning significantly reduced infarct area and improved neurological function when the ischaemic insult occurred 3 weeks later. Hemin promoted and zinc protoporphyrin blocked this protection, implicating HO-1, which was expressed more strongly in the border zone than the necrotic…
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