The dose of cyclophosphamide for treating paraquat-induced rat lung injury.
RatChemical/toxinSprague-DawleyMalen = Control n=5; paraquat alone n=10; paraquat plus cyclophosph…Intraperitoneal1.5, 15 or 30 mg/kgImmediately after the paraquat injection
Model: Paraquat 35 mg/kg intraperitoneally in 1 ml saline, a dose giving about 60 per cent mortality; endpoint at 72 hours
Cyclophosphamide reduced micro-CT lesion extent and histological inflammation, with 15 mg/kg clearly better than 1.5 mg/kg and 30 mg/kg giving no further benefit, so 15 mg/kg was judged optimal. Antioxidant enzyme activity was restored and elevated serum TGF-beta1 reduced, although IL-6 and TNF-alp…
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