Administration of TSG-6 improves memory after traumatic brain injury in mice.
MouseTBIControlled cortical impactC57BL/6jMaleIntravenous, tail veinTSG-6 50 microgram per mouse in 200 microlitre PBS; 10 and…6 hours after controlled cortical impact, with a second dose in some mice at 24…
Model: Controlled cortical impact via 4 mm craniectomy over right temporo-parietal cortex; single impact of 0.8 mm deformation depth, 4.5 m/s velocity, 250 ms dwell, 3 mm impactor tip; sham was craniectomy without impact
Intravenous TSG-6 during the early inflammatory phase reduced neutrophil infiltration and MMP9 activity at 24 h, reduced blood brain barrier leakage at day 3 and cut hemisphere lesion volume by about 40 per cent. It also improved spatial learning, working memory, depressive-like behaviour and newbo…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.