Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal Cells.
MouseRadiationC3H/HeNMalen = Merged repeat experiments of 9 to 12 mice per arm; main sur…Intramuscular, into two sites in the thigh muscle of each hind limb2 million cells per injection in 100 microlitre given as 4…First injection 24 h after irradiation, with delayed start arms at 48 h or 72 h…
Model: Total body irradiation with a clinical 6 to 18 MeV linear accelerator; main survival model 7.7 Gy giving about 30 per cent control survival, with 6 Gy and 8.5 Gy arms and escalating doses for dose modifying factor estimation
PLX-RAD raised survival after 7.7 Gy from about 27 per cent in vehicle controls to 97 to 98 per cent, while PLX-Mat raised it to about 67 to 68 per cent, giving a dose modifying factor of about 1.22 to 1.23. Treated mice recovered weight, bone marrow cellularity, progenitor fraction and blood count…
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