Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds.
RatWoundSprague-DawleyFemalen = n=3 rats per treatment per time point across 3 cohorts at 4…Topical application of liquid pre-polymer onto the wound bed, gelling in situ in about 1 to 2 min400 microlitre of cell laden biomatrix applied to the wound…Immediately after wound creation, under the same anaesthesia
Model: Full thickness excisional cutaneous wounds on the dorsum made with an 8 mm biopsy punch under isoflurane, with silicone rings sutured to prevent healing by contraction
The cell laden biomatrix gave significantly greater 7 day wound closure than sham (66 plus or minus 5 per cent versus 25 plus or minus 18 per cent, p=0.019), faster re-epithelialisation, reduced polymorphonuclear infiltration and no foreign body giant cells. However the acellular hydrogel achieved…
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