Effect of sodium hydrosulphide after acute compression injury of spinal cord.
RatSpinal cord injuryCompressionWistarMaleIntraperitoneal50 micromolar1 hour after injury
Model: Spinal cord clip compression injury at T8 to T10 after laminectomy, using a 35 g clip for 1 min; tissue collected 8 h after injury
Sodium hydrosulphide reduced nitric oxide by 27 per cent, lipid peroxide by 18 per cent, myeloperoxidase by 10 per cent and GFAP by 8 per cent, and increased glutathione by 44 per cent and Nrf-2 expression 1.8 fold relative to injury alone. There was no significant change in NF-200 and no evident m…
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