BML-111, a lipoxin receptor agonist, ameliorates 'two-hit'-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1.

BML-111, a lipoxin receptor agonist, ameliorates 'two-hit'-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1.

Model: Acute pancreatitis-associated lung injury produced by seven hourly intraperitoneal injections of cerulein followed immediately by a single dose of Escherichia coli lipopolysaccharide (two-hit model)

Pretreatment with BML-111 lowered serum amylase, TNF-alpha and IL-1 beta, raised IL-10, reduced lung wet to dry weight ratio and pancreatic and pulmonary histological injury scores, and increased pulmonary heme oxygenase-1 expression compared with the untreated injury group.

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