Heparin-binding epidermal growth factor-like growth factor attenuates acute lung injury and multiorgan dysfunction after scald burn.
MouseBurnScaldC57BL/6MaleEnteral (gastric gavage)1200 microg/kg per dose, two doses (2400 microg/kg total) i…Pretreatment, 12 h and 1 h before burn
Model: Full-thickness dorsal scald burn over approximately 25% of total body surface area, produced by submersion in 100 degrees C water for 10 s, with subcutaneous saline spinal protection and intraperitoneal Ringer's lactate resuscitation; sacrifice at 8 h
Enteral HB-EGF pretreatment reduced lung myeloperoxidase (3.2 +/- 2.1 vs 7.6 +/- 2.1 U/g, p = 0.003), pulmonary cleaved caspase 3 positive cells (0.7 +/- 0.5 vs 5.3 +/- 1.9 per high power field, p = 0.00006), splenic cleaved caspase 3 and intestinal permeability (21.2 +/- 13.5 vs 47.9 +/- 26.9 mL/m…
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