Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration.
MouseChemical/toxinBALB/cMalen = Approximately 22 mice in total (6 in the 70% injury group,…Topical to the corneal surface, compared with intralimbal injection2 x 10(5) cells in 5 microL phosphate-buffered saline per a…Started on the day of injury after epithelial debridement
Model: Alkali corneal burn produced by applying 0.5 N NaOH-soaked filter paper to the corneal surface for 30 s followed by epithelial debridement; paper covering either 70% of the central cornea (limbal-sparing, 5.9 mm) or 100% of the cornea (limbal-involved, 7 mm)
Topical orbital fat-derived stem cells accelerated corneal re-epithelialisation (limbal-involved injury: residual defect 15.0 +/- 7.83% at day 3 and 7.9 +/- 2.34% at day 7 versus 42.0 +/- 2.74% and 29.3 +/- 6.78% with phosphate-buffered saline), reduced stromal infiltration, CD68 and iNOS, and impr…
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