Effects of hyaluronic acid conjugation on anti-TNF-alpha inhibition of inflammation in burns.
RatBurnContact / flameSprague-Dawleyn = 16 rats, 4 per groupTopical to the debrided burn wound under Tegaderm dressing200 microL per application of 5% hyaluronic acid conjugate…First treatment on day 0, the day after burn, immediately after eschar excision
Model: Deep partial-thickness contact burn made with a 17 mm brass disc weighted with 500 g and heated to 85 degrees C applied to shaved dorsal skin for 10 s, with eschar excision the following day (day 0)
The hyaluronic acid conjugate produced the greatest reduction in non-viable tissue at day 7 (p < 0.003 versus all other treatments) and lowered IL-1beta versus saline at days 4 and 7, whereas non-conjugated antibody reduced macrophage counts most (approximately 75% below saline at days 4 and 7) but…
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