Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability.
MouseWoundC57BL/6 endoglin heterozygous null (Eng+/-) and wild-type littermatesFemale
Model: Cutaneous full-thickness skin wound in endoglin heterozygous null mice with reepithelialisation followed for up to 8 days; acute 12-O-tetradecanoylphorbol-13-acetate stimulation used as a separate hyperplasia challenge
Wound area was larger in endoglin heterozygous mice from 2 to 8 days after injury with closure delayed by 1 to 2 days, and the nitric oxide donor LA-803 accelerated wound closure in endoglin heterozygous mice with no effect in normal littermates
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.