Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleAfter injury; exact timing not stated
Model: Rat traumatic brain injury model in vivo, with an accompanying in vitro astrocyte scratch assay
Histone deacetylase inhibitor treatment after traumatic brain injury preserved nerve growth factor and TrkA signalling, shifted protein expression towards survival and away from apoptosis, increased nestin and reduced GFAP in damaged tissue
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.