Adult bone marrow neural crest stem cells and mesenchymal stem cells are not able to replace lost neurons in acute MPTP-lesioned mice.
MouseChemical/toxinC57BL/6JMalen = n at least 3 per group at each time point; n = 5 for TH-pos…Intrastriatal stereotaxic injection of cells suspended in 2 microlitres PBS (right striatum)Cell graft five days after MPTP lesioning
Model: Acute MPTP lesion: four intraperitoneal injections of MPTP-HCl 20 mg/kg at two-hour intervals
Grafted NCSC and MSC survived only transiently, did not migrate or change phenotype, and produced no recovery of dopaminergic system integrity.
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